Evaluation of tablet:
The evaluation of the tablet is a essential step for the complete dosage form design of the tablet.
There are some parameters which are important for the evaluation of the tablet are:
1. General appearance
2. Unique identification marking
3. Size and shape
4. Organoleptic properties
5. Weight and weight variation.
6. Content uniformity
7. Hardness
8. Friability
9. Thickness
10. Disintegration test
11. Dissolution rate
There are some parameters which are important for the evaluation of the tablet are:
1. General appearance
2. Unique identification marking
3. Size and shape
4. Organoleptic properties
5. Weight and weight variation.
6. Content uniformity
7. Hardness
8. Friability
9. Thickness
10. Disintegration test
11. Dissolution rate
1. General Appearance:
The first and simple method to evaluate a tablet is its general appearance which include the taste, presence of odor, color and surface texture etc, the general appearance is preferred to the identity of a tablet. And it also help to prepare a batch of tablet with the same size, shape and texture.
The first and simple method to evaluate a tablet is its general appearance which include the taste, presence of odor, color and surface texture etc, the general appearance is preferred to the identity of a tablet. And it also help to prepare a batch of tablet with the same size, shape and texture.
2. Size and shape:
The size and shape of a tablet is an essential part. The tablet should be in uniform shape and size. The size and shape is depend on the material which are used and the process which are used to prepare the tablet.
The size and shape of a tablet is an essential part. The tablet should be in uniform shape and size. The size and shape is depend on the material which are used and the process which are used to prepare the tablet.
3. Unique identification marking:
Pharmaceutical companies uses a specific color or printing on the tablet for the rapid identification of the product of their company. Many company uses their trademark or a specific symbol on the tablet.
Pharmaceutical companies uses a specific color or printing on the tablet for the rapid identification of the product of their company. Many company uses their trademark or a specific symbol on the tablet.
4. Organoleptic properties:
As per the unique identification marking, many company uses specific color, printing and some time two colors in a tablet for the rapid identification and also for making tablet attractive for the patient.
As per the unique identification marking, many company uses specific color, printing and some time two colors in a tablet for the rapid identification and also for making tablet attractive for the patient.
5. Weight and weight variation:
The weight and weight variation test is essential to ensure that the all tablets in a batch having same potency with a specific limit. The weight of all tablets should be uniform.
And the variation limits are ±10 % for tablet weight 130mg or less,
±7.5 % for tablet weight more than 130mg and upto 324mg,
And ±5 % for tablet weight 325mg or more.
The weight and weight variation test is essential to ensure that the all tablets in a batch having same potency with a specific limit. The weight of all tablets should be uniform.
And the variation limits are ±10 % for tablet weight 130mg or less,
±7.5 % for tablet weight more than 130mg and upto 324mg,
And ±5 % for tablet weight 325mg or more.
6. Content uniformity:
The tablet contains the active ingredients should be in uniform manner. According to label claim the standard deviation is less than 6%. The active ingredients in dosage form should be lies between 85% to 115%.
The tablet contains the active ingredients should be in uniform manner. According to label claim the standard deviation is less than 6%. The active ingredients in dosage form should be lies between 85% to 115%.
7. Hardness:
The hardness is a value which is required to crush the tablet in hardness tester machine. Generally it is express in term of load/pressure. There are some tester that are used to determine hardness are given below:
a. Monsanto tester
b. Strong-cobb tester
c. Pfizer tester
d. Erweka tester
e. Schleuniger tester
The hardness is a value which is required to crush the tablet in hardness tester machine. Generally it is express in term of load/pressure. There are some tester that are used to determine hardness are given below:
a. Monsanto tester
b. Strong-cobb tester
c. Pfizer tester
d. Erweka tester
e. Schleuniger tester
8. Friability:
For the testing of friability, an apparatus is used namely Roche friabilator.
The friability test is used for the determination of physical stability when tablet faces friction, shock and breaks. The apparatus consist of 2-3 compartments, this chamber rotates at the speed of 25 RPM and the tablet is dropdown with the height of 15 cm with each revolution.
For the testing of friability, an apparatus is used namely Roche friabilator.
The friability test is used for the determination of physical stability when tablet faces friction, shock and breaks. The apparatus consist of 2-3 compartments, this chamber rotates at the speed of 25 RPM and the tablet is dropdown with the height of 15 cm with each revolution.
9. Thickness:
The thickness of a tablet is generally measured in micrometer. According to standard thickness of a tablet, the deviation should not by ±5% . the variation in thickness of tablet may cause problem in packaging.
The thickness of a tablet is generally measured in micrometer. According to standard thickness of a tablet, the deviation should not by ±5% . the variation in thickness of tablet may cause problem in packaging.
10. Disintegration test:
This test is used to determine the disintegration rate of both coated and Uncoated tablet in a prescribed time when tablet placed in a liquid medium.
Method: one tablet is placed in each of 6 tubes of basket add all the discs to each tubes, the apparatus is filled up with water having temp. 37’C , when all tablets disintegrates in less than 15 minutes , the tablets passes the test.
This test is used to determine the disintegration rate of both coated and Uncoated tablet in a prescribed time when tablet placed in a liquid medium.
Method: one tablet is placed in each of 6 tubes of basket add all the discs to each tubes, the apparatus is filled up with water having temp. 37’C , when all tablets disintegrates in less than 15 minutes , the tablets passes the test.
11. Dissolution Rate:
The dissolution rate plays important role in the mechanism of drug absorption. Drug absorbs when it comes in the contact with liquid medium. so the dissolution rate of a tablet is important for the absorption in the stomach.
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